广东省杰出青年基金获得者、广东省特支计划入选者?/strong>近年来在生物与化学的界面上、探索核酸化学、光电化学传感、特异性生物识别等前沿基础科学问题，以电化学发光技术、纳米探针技术、单分子荧光光谱等为研究工具，研究新型生物传感原理和方法，以求实现一些重要生物功能分子的功能调控和高精度识别和定量，为疾病诊断、食品安全、环境监测提供新的分析技术与工具。相关工作发表在Nature Protocols, Chemical Society Reviews, Biomaterials, Analytical Chemistry, Lab on a Chip, Biosensors and Bioelectronics，ACS Appl. Mater. Interfaces, Biomacromolecules, Chemical Communications,等生物技术和生物传感领域国际权威期刊?/span>IF>5 刊物 41 篇，截止目前被引?/span>1558次，H因子23?/span>。作为主要完成人获得教育部自然科学成果二等奖（新型生物传感技术在功能分子检测和成像中的应用基础研究），获得授权发明专利10项?015年获得广东省科技创新青年拔尖人才?014年获得广东省杰出青年基金、广东省高等学校优秀青年教师培养对象资助?013年获得广州市珠江科技新星资助?/span>
学习工作经历?/span>
学士 (2005), 湖南文理学院生物系；
博士 (2005?010), 华南师范大学激光生命科学教育部重点实验室；
讲师?010-2012），华南师范大学激光生命科学教育部重点实验室；
副研究员?013-2015? 华南师范大学激光生命科学教育部重点实验室；
特聘研究员（2015-至今? 华南师范大学激光生命科学教育部重点实验室；
访问学者（2014-2015），武汉大学化学与分子科学学?/span>
学术兼职?/strong>
中国光学学会生物医学光子学学会专?2015-至今
中国生物医学工程学会光子学学会专?2015-至今
《激光生物学报》常务编?nbsp; 2013-至今
《分析测试学报》青年编?nbsp; 2017-至今
广东省青年科学家协会 2015?至今
中国生物物理学会 2010-至今
广东省生物医学工程学?nbsp; 2011-至今
《Nucleic Acids Research?《Clinical Chemistry》、《Analytical Chemistry》、《Biosensors and Bioelectronics》、《ACS Applied Materials & Interfaces》、?span style="color: windowtext; font-family: 'times new roman';">Environmental Science & Technology》，《ACS Sensors?/span>、《Sensors & Actuators: B. Chemical》、《Journal of Agricultural and Food Chemistry》、《Analytica Chimica Acta》、《Analyst》、《Colloids and Surfaces B: Biointerfaces》、《Analytical and Bioanalytical Chemistry?/span>等生物化学领域权威刊物审稿人?/span>
?年代表性论?/strong>?/strong>
1. Xiaoming Zhou, DebinZhu, Yuhui Liao, Weipeng Liu, Hongxing Liu, Zhaokui Ma, Da Xing*, Synthesis, labelling, and bioanalytical applications of a tris (2, 2'-bipyridyl) ruthenium (II) based electrochemiluminescence probe, Nature Protocols 2014, 9, 1146-1159.
2. Xiaoming Zhou, and Da Xing*, Assays for human telomerase activity: progress and prospects, Chemical Society Reviews 2012, 41, 4643-4656.
3. Huahua Yue, Xiaoming Zhou, Da Xing*, Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing, Nanoscale 2018, 10, 1063-1071.
4. Mengqi Huang, Xiaoming Zhou*, Huiying Wang, and Da Xing*, CRISPR/Cas9 triggered isothermal amplification for site-specific nucleic acid detection, Analytical Chemistry 2018, DOI: 10.1021/acs.analchem.7b04542.
5. Yu Fu, Xiaoming Zhou* and Da Xing*, Lab-on-capillary: a rapid, simple and quantitative genetic analysis platform integrating nucleic acid extraction, amplification and detection, Lab on a Chip 2017, 17, 4334-4341.
6. Yuhui Liao, Xiaoming Zhou, Yu Fu, and Da Xing*, Linear Ru(bpy)32+−Polymer as a Universal Probe for Sensitive Detection of Biomarkers with Controllable Electrochemiluminescence Signal-Amplifying Ratio, Analytical Chemistry 2017, 89, 13016?3023.
7. Weipeng Liu, Huiheng Yu, Xiaoming Zhou*, and Da Xing*, In Vitro Evaluation of CRISPR/Cas9 Function by an Electrochemiluminescent Assay, Analytical Chemistry 2016, 88, 8369-8374.
8. Hongxing Liu, Xiaoming Zhou*, Weipeng Liu, Xiaoke Yang, and Da Xing*, Paper-Based Bipolar Electrode Electrochemiluminescence Switch for Label-Free and Sensitive Genetic Detection of Pathogenic Bacteria, Analytical Chemistry 2016, 88, 10191-10197.
9. Ting Zhou, Xiaoming Zhou*, Da Xing*, Controlled release of doxorubicin from graphene oxide based charge-reversal nanocarrier, Biomaterials 2014, 35, 4185-4194.
10. Yuhui Liao, Ru Huang, Zhaokui Ma, Yunxia Wu, Xiaoming Zhou*, and Da Xing*, A target-triggered enzyme-free amplification strategy for sensitive detection of microRNA in tumor cells and tissues, Analytical Chemistry 2014, 86, 4596-4604.
获奖?/strong>
教育?012年度高校科研优秀成果二等?（排名第四）
新型生物传感技术在功能分子检测和成像中的应用基础研究
主持科研、人才基金：
1. 广东省自然科学杰出青年基金（2014-2018）：
重要病原微生物的核酸分子诊断新策略及新技术研究?nbsp;
2. 广东省特支计划科技创新青年拔尖人才项目?015）：
3. 广东省高等学校优秀青年教师培养对象?014-2016）：
4. 国家自然科学基金面上项目?015-2018）：
适配体靶向与转运的功能化核酸探针构建及端粒酶活性调控与分析
5. 国家自然科学基金青年项目?012-2014）：
基于单分子荧光光谱与核酸探针的均相生物传感新方法与技术研?nbsp;
6. 广州市珠江科技新星专项?013-2016）：
纳米探针在人端粒酶生物学上的基础研究：功能调控及活性检?nbsp;
7. 广东省自然科学基金（2011-2013）：
基于荧光相关光谱与适配体的均相生物传感新方法与技术研?/span>
1. Huahua Yue, Xiaoming Zhou*, Da Xing*, Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing, Nanoscale 2018, 10, 1063-1071.
2. Mengqi Huang, Xiaoming Zhou*, Huiying Wang, and Da Xing*, CRISPR/Cas9 triggered isothermal amplification for site-specific nucleic acid detection, Analytical Chemistry 2018, DOI: 10.1021/acs.analchem.7b04542.
3. Bofan Li, Xiaoming Zhou*, Hongxing Liu, Huaping Deng, Ru Huang, Da Xing*, Simultaneous detection of antibiotic resistance genes on paper-based chip using [Ru(phen)2dppz]2+ photoswitch probe, ACS Appl. Mater. Interfaces 2018, DOI: 10.1021/acsami.7b17653.
4. Yu Fu, Xiaoming Zhou* and Da Xing*, Integrated Paper-based Detection Chip with Nucleic Acid Extraction and Amplification for Automatic and Sensitive Pathogen Detection, Sensors & Actuators: B. Chemical 2018, Accepted.
5. Meng Cheng, Xiaoming Zhou* and Da Xing*, Peptide cleavage induced assembly enables highly sensitive electrochemiluminescence detection of protease activity, Sensors & Actuators: B. Chemical 2018, in revision.
6. Hongxing Liu, Xiaoming Zhou*, Qi Shen, and Da Xing*, Paper-based electrochemiluminescence sensor for highly sensitive detection amyloid‑?oligomerization: Toward potential diagnosis of Alzheimer’s disease, Theranostics 2018, in revision.
7. Yu Fu, Xiaoming Zhou* and Da Xing*, Lab-on-capillary: a rapid, simple and quantitative genetic analysis platform integrating nucleic acid extraction, amplification and detection, Lab on a Chip 2017, 17, 4334-4341.
8. Yuhui Liao, Xiaoming Zhou*, Yu Fu, and Da Xing*, Linear Ru(bpy)32+−Polymer as a Universal Probe for Sensitive Detection of Biomarkers with Controllable Electrochemiluminescence Signal-Amplifying Ratio, Analytical Chemistry 2017, 89, 13016?3023.
9. Huaping Deng, Xiaoming Zhou*, Qianwen Liu, Bofan Li, Hongxing Liu, Ru Huang, and Da Xing*, Paperfluidic Chip Device for Small RNA Extraction, Amplification, and Multiplexed Analysis, ACS Appl. Mater. Interfaces 2017, 9, 41151?1158.
10. Xiaoke Yang, Xiaoming Zhou*, Minjun Zhu, Da Xing*, Sensitive detection of Listeria monocytogenes based on highly efficient enrichment with vancomycin-conjugated brush-like magnetic nano-platforms, Biosensors and Bioelectronics 2017, 91, 238-245.
11. Huaping Deng, Qianwen Liu, Xin Wang, Ru Huang, Hongxing Liu, Qiumei Lin, Xiaoming Zhou* and Da Xing*, Quantum Dots-Labeled Strip Biosensor for Rapidand Sensitive Detection of MicroRNA Based on Target-Recycled Nonenzymatic Amplification Strategy, Biosensors and Bioelectronics 2017, 87, 931?40.
12. Ru Huang, Yuhui Liao, Xiaoming Zhou*, Yu Fu, Da Xing*, Multiplexed detection of microRNA biomarkers from tumor cells andtissues with a homogeneous nano-photon switch, Sensors & Actuators: B. Chemical 2017, 247, 505?13.
13. Hongxing Liu, Xiaoming Zhou*, Jinjin Shen, and Da Xing*, Sensitive Detection of Hg2+ with Switchable Electrochemiluminescence Luminophore and Disposable Bipolar Electrode, ChemElectroChem 2017, 4, 1681?685.
14. Weipeng Liu, Minjun Zhu, Hongxing Liu, Jitao Wei, Xiaoming Zhou* and Da Xing*, Invading stacking primer: a trigger for high-efficiency isothermal amplification reaction with superior selectivity for detecting microRNA variants, Biosensors and Bioelectronics 2016, 81, 309?16.
15. Lisha Zhang, Xiaoming Zhou* and Da Xing*, Rapid and Visual Detection of Listeria monocytogenes Based on Nanoparticle Cluster Catalyzed Signal Amplification, Biosensors and Bioelectronics 86, (2016), 1-7
16. Weipeng Liu, Huiheng Yu, Xiaoming Zhou,* and Da Xing*, In Vitro Evaluation of CRISPR/Cas9 Function by an Electrochemiluminescent Assay, Analytical Chemistry 2016, 88, 8369-8374.
17. Hongxing Liu, Xiaoming Zhou*, Weipeng Liu, Xiaoke Yang, and Da Xing*, Paper-Based Bipolar Electrode Electrochemiluminescence Switch for Label-Free and Sensitive Genetic Detection of Pathogenic Bacteria, Analytical Chemistry 2016, 88, 10191-10197.
18. Qianwen Ding, Qiuqiang Zhan, Xiaoming Zhou, Tao Zhang* and Da Xing*, Theranostic Upconversion Nanobeacons for Tumor mRNA Ratiometric Fluorescence Detection and Imaging-Monitored Drug Delivery, Small 2016, 12, 5944-5953.
19. Fang Liu, Hongxing Liu,Yuhui Liao,Jitao Wei, Xiaoming Zhou* and Da Xing*, Multiplex detection and genotyping of pathogenic bacteria on paper-based biosensor with a novel universal primer mediated asymmetric PCR, Biosensors and Bioelectronics 2015,74, 778?85.
20. Minjun Zhu, Weipeng Liu, Hongxing Liu, Yuhui Liao, Jitao Wei, Xiaoming Zhou* and Da Xing* Construction of Fe3O4/Vancomycin/PEG Magnetic Nanocarrier for Highly Efficient Pathogen Enrichment and Gene Sensing, ACS Appl. Mater. Interfaces 2015, 7, 12873?2881.
21. Yuhui Liao, Yu Fu, Yunxia Wu, Ru Huang, Xiaoming Zhou* and Da Xing*, Ultrasensitive Detection of MicroRNA in Tumor Cells and Tissues via Continuous Assembly of DNA Probe, Biomacromolecules 2015, 16, 3543?551.
22. Ru Huang, Yuhui Liao, Xiaoming Zhou*, Da Xing*, Toehold-mediated nonenzymatic amplification circuit on grapheme oxide fluorescence switching platform for sensitive and homogeneous microRNA detection, Analytica Chimica Acta 2015, 888, 162-172.
23. Xiaoming Zhou, DebinZhu, Yuhui Liao, Weipeng Liu, Hongxing Liu, Zhaokui Ma, Da Xing*, Synthesis, labelling, and bioanalytical applications of a tris (2, 2'-bipyridyl) ruthenium (II) based electrochemiluminescence probe, Nature Protocols 2014, 9, 1146-1159.
24. Ting Zhou, Xiaoming Zhou*, Da Xing*, Controlled release of doxorubicin from graphene oxide based charge-reversal nanocarrier, Biomaterials 2014, 35, 4185-4194.
25. Yuhui Liao, Ru Huang, Zhaokui Ma, Yunxia Wu, Xiaoming Zhou*, and Da Xing*, A target-triggered enzyme-free amplification strategy for sensitive detection of microRNA in tumor cells and tissues, Analytical Chemistry 2014, 86, 4596-4604.
26. Weipeng Liu, Xiaoming Zhou*, Da Xing*, Rapid and reliable microRNA detection by stacking hybridization on electrochemiluminescent chip system, Biosensors and Bioelectronics 2014, 58, 388?94.
27. Hongxing Liu, Fangfang Zhan, Fang Liu,Minjun Zhu, Xiaoming Zhou* and Da Xing*, Visual and sensitive detection of viable pathogenic bacteria by sensing of RNA markers in gold nanoparticles based paper platform, Biosensors and Bioelectronics 2014, 62, 38?6.
28. Yuhui Liao, Xiaoming Zhou* and Da Xing*, Quantum Dots and Graphene Oxide Fluorescent Switch Based Multivariate Testing Strategy for Reliable Detection of Listeria monocytogenes, ACS Appl. Mater. Interfaces 2014, 6, 9988?996.
29. Jitao Wei, Hongxing Liu, Fang Liu, Minjun Zhu, Xiaoming Zhou*, Da Xing* Miniaturized Paper-Based Gene Sensor for Rapid and Sensitive Identification of Contagious Plant Virus, ACS Appl. Mater. Interfaces 2014, 6, 22577?2584.
30. Jianzhi Liu; Yongjun Hu*; Guichi Zhu; Xiaoming Zhou; Li Jia; Tao Zhang，Highly Sensitive Detection of Zearalenone in Feed Samples Using Competitive Surface-Enhanced Raman Scattering Immunoassay?/span>Journal of Agricultural and Food Chemistry 2014, 62, 8325-8332.
31. Yi Long, Xiaoming Zhou*, Da Xing*, An isothermal and sensitive nucleic acids assay by target sequence recycled rolling circle amplification, Biosensors and Bioelectronics 2013, 46, 102-107
32. Zhongyu Fu, Xiaoming Zhou*, Da Xing*, Sensitive colorimetric detection of Listeria monocytogenes based on isothermal gene amplification and unmodified gold nanoparticles, Methods 2013,64, 260?66.
33. Zhongyu Fu, Xiaoming Zhou*, Da Xing*, Rapid colorimetric gene-sensing of food pathogenic bacteria using biomodification-free gold nanoparticle, Sensors & Actuators: B. Chemical 2013,182, 633?41.
34. Xiao Zhu, Xiaoming Zhou, Da Xing*, Label-Free Detection of MicroRNA: Two-Step Signal Enhancement with a Hairpin-Probe-Based Graphene Fluorescence Switch and Isothermal Amplification, Chemistry A European Journal 2013, 19, 5487?494.
35. Fangfang Zhan, Xiaoming Zhou, Da Xing*, Rapid and sensitive electrochemiluminescence detection of rotavirus by magnetic primer based reverse transcription-polymerase chain reaction, Analytica Chimica Acta 2013, 761, 71-77.
36. Xiaoming Zhou, Yuhui Liao, Da Xing*, Sensitive monitoring of RNA transcription levels using a graphene oxide fluorescence switch, Chinese Science bulletin 2013, 21: 2634-2639.
37. Xiaoming Zhou, and Da Xing*, Assays for human telomerase activity: progress and prospects, Chemical Society Reviews 2012, 41, 4643-4656.
38. Liyun Xue, Xiaoming Zhou (co-first author), and Da Xing*, Sensitive and Homogeneous Protein Detection Based on Target- Triggered Aptamer Hairpin Switch and Nicking Enzyme Assisted Fluorescence Signal Amplification, Analytical Chemistry 2012, 84, 3507?513.
39. Xiaoming Zhou, Qiang Su, Da Xing*, An electrochemiluminescent assay for high sensitive detection of mercury (II) based on isothermal rolling circular amplification?/span>Analytica Chimica Acta 2012, 713, 45?9.
40. Xiaoming Zhou, Ruixue Duan, and Da Xing*, Highly sensitive detection of protein and small molecules based on aptamer-modified electrochemiluminescence nanoprobe, Analyst 2012, 137, 1963-1969.
41. Xiaoming Zhou,, Da Xing*, Amplified electrochemiluminescence detection of nucleic acids by hairpin probe based isothermal amplification, Analyst 2012, 137, 4188-4192.
42. Zhen Zhao, Xiaoming Zhou*, Ultrasensitive electrochemiluminescence detection of mercury ions based on DNA oligonucleotides and cysteamine modified gold nanoparticles probes, Sensors & Actuators: B. Chemical 2012 (171?72) 860?865.
43. Zhen Zhao, Xiaoming Zhou, Da Xing*, Highly sensitive protein kinase activity assay based on electrochemiluminescence nanoprobes, Biosensors and Bioelectronics 2012, 31, 299-304.
44. Xiao Zhu, Xiaoming Zhou, Da Xing*, Nano-magnetic primer based electrochemiluminescence-polymerase chain reaction (NMPE-PCR) assay, Biosensors and Bioelectronics 2012, 31, 463-468.
45. Xiaoming Zhou, Yonghong Tang, and Da Xing*, One-Step Homogeneous Protein Detection Based on Aptamer Probe and Fluorescence Cross-Correlation Spectroscopy, Analytical Chemistry 2011, 83, 2906?912.
46. Yi Long, Xiaoming Zhou, Da Xing*, Sensitive and isothermal electrochemiluminescence gene-sensing of Listeria monocytogenes with hyperbranching rolling circle amplification technology, Biosensors and Bioelectronics 2011, 26, 2897-2904.
47. Xiao Zhu, Xiaoming Zhou, Da Xing*, Ultrasensitive and Selective Detection of Mercury (? in Aqueous Solution by Polymerase Assisted Fluorescence Amplification, Biosensors and Bioelectronics 2011, 26, 2666-2669.
48. Ruixue Duan, Xiaoming Zhou (co-first author), Da Xing*, Electrochemiluminescence Biobarcode Method Based on Cysteamine-Gold Nanoparticle Conjugates, Analytical Chemistry 2010, 82, 3099-3103.
49. Jie Wei, Xiaoming Zhou (co-first author), Da Xing*, Rapid and sensitive detection of vibrio parahaemolyticus in sea foods by electrochemiluminescence polymerase chain reaction method, Food Chemistry 2010, 123, 852-858.
50. Liyun Xue, Xiaoming Zhou and Da Xing*, Highly sensitive protein detection based on aptamer probe and isothermal nicking enzyme assisted fluorescence signal amplification, Chemical Communications 2010, 46, 7373?375.
51. Qiang Li, Xiaoming Zhou, Da Xing*, Rapid and highly sensitive detection of mercury ion (Hg2+) by magnetic beads-based electrochemiluminescence assay, Biosensors and Bioelectronics 2010, 26, 859-862.
52. Qiang Su, Da Xing*, Xiaoming Zhou, Magnetic beads based rolling circle amplification–electrochemiluminescence assay for highly sensitive detection of point mutation, Biosensors and Bioelectronics 2010, 25, 1615-1621.
53. Debin Zhu, Xiaoming Zhou, Da Xing*, A new kind of aptamer-based immunomagnetic electrochemiluminescence assay for quantitative detection of protein, Biosensors and Bioelectronics 2010, 26, 285-288.
54. Xiaoming Zhou, Da Xing*, Debin Zhu, Li Jia, Magnetic bead and nanoparticle based electrochemiluminescence amplification assay for direct and sensitive measuring of telomerase activity, Analytical Chemistry 2009, 81, 255-261.
55. Xiaoming Zhou, Da Xing*, Yonghong Tang, and Wei R. Chen, PCR-Free Detection of Genetically Modified Organisms Using Magnetic Capture Technology and Fluorescence Cross-Correlation Spectroscopy, PLoS One 2009, 4, e8074.
56. Huijuan Zhou, Da Xing*, Debin Zhu, and Xiaoming Zhou, Rapid and sensitive detection of point mutation by DNA ligase-based electrochemiluminescence assay, Talanta 2009, 78, 1253-1258.
57. Xiaoming Zhou, Da Xing*, Debin Zhu and Li Jia, Magnetic beads-based electrochemiluminescence assay for rapid and sensitive detection of telomerase activity, Electrochemistry Communications 2008, 10, 564-567.
58. Xiaoming Zhou, Da Xing*, Debin Zhu, Yabing Tang, and Li Jia, Development and application of a capillary electrophoresis- electrochemiluminescent method for the analysis of enrofloxacin and its metabolite ciprofloxacin in milk, Talanta 2008, 75, 1300?306.
59. Jie Wei, Xiaoming Zhou*, An improved electrochemiluminescence polymerase chain reaction method for the detection of Fusarium wilts, Chinese Chemical Letters 2008, 19, 959?61.
